Study suggests immunotherapy may help overcome trastuzumab-resistance in breast cancer

3D mammogram or digital tomosynthesis

WISDOM, or Women Informed to Screen Depending on Measures of Risk, study hopes to find the right way to screen women for breast cancer.

MONALEESA-7 is the first prospective global phase III trial in more than 20 years, designed specifically for premenopausal women diagnosed with advanced breast cancer, to demonstrate superiority of any CDK4/6 inhibitor in combination with oral hormonal therapies and goserelin versus endocrine treatment alone in this patient population. "There is a clear need to develop new therapeutic approaches for patients presenting with HER2-positive metastatic breast cancer that has become resistant to trastuzumab". Women taking Kisqali also had a clinically meaningful improvement in pain symptoms as early as eight weeks and this improvement was sustained.

No additional safety signal was identified in the MONALEESA-7 study.

These drugs - which include Arimidex, Femara and Aromasin, among others - are often used to treat women with estrogen-sensitive breast tumors, Hershman said.

Hershman's team wondered if the ancient practice of acupuncture might help.

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Two B-1B Lancers stage drills on western coast of Korean peninsula
A total of 12,000 U.S. service members are taking part in the annual Vigilant Ace drills alongside South Korean troops. North Korea regularly uses its state media to threaten the United States and its allies.

After six weeks, patients in the true acupuncture group reported much lower pain scores than those in either the fake acupuncture or waiting list groups, Hershman's team reported.

"Longer follow-up is needed to determine whether the trial will meet its secondary end point of overall survival", Tripathy said in a statement.

"Given these results, healthcare practitioners may want to discuss the possibility of acupuncture with patients experiencing treatment-related joint pain and stiffness because it has the potential to improve their quality of life", said Dr. Hershman, who is also Vice Chairman of the Southwest Oncology Group, a National Cancer Institute-funded clinical trials network.

Dr. Cynara Coomer directs the Florina Rusi-Marke Comprehensive Breast Center, at Staten Island University Hospital in New York City. has more on aromatase inhibitors.

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