Artificial ovary could help women conceive after chemotherapy

It is hoped an engineered structure could be re-implanted into women and restore fertility after they have completed chemotherapy or radiotherapy

Researchers in Denmark have made the first steps towards creating an "artificial" ovary in what could improve fertility preservation treatments.

In their recent experiment, the scientists took ovarian follicles and tissue from patients before they received cancer treatment and proceeded to remove the cancerous cells from the collected tissue, filling up the gaps with a "scaffold" made up of proteins and collagen.

According to Pors and her team, if the ovarian tissues can be bioengineered onto a scaffold and seeded with previously frozen early-stage follicles, these could go on to develop naturally and could help in bringing the fertility back in the patient without the risk of her getting possible cancer cells reintroduced within her body. She presented the results at the European Society of Human Reproduction and Embryology's annual conference in Barcelona, Spain, on Monday. They also successfully grafted follicles which then grew to become normal eggs.

One way women can preserve their chances of conceiving is with an ovarian tissue transplant, where all or part of the ovary is removed and frozen before it is damaged so that it can be used at a later date. An "artificial ovary" could reduce this risk.

Scientists say that human trials will start no earlier than 5-10 years. Such treatments increase the risk of infertility as they can stop the ovaries from working properly.

Yerry Mina focused on Barcelona after World Cup heroics with Colombia
It remains to be seen if either side are in negotiations to sign the Colombia defender. He added: "In my head right now, I am thinking about returning to Barca".

Now their best option is to freeze their eggs before problems in the ovary start and then undergo potentially gruelling IVF. Unlike ovarian tissues, follicles do not contain cancer cells. The team developed the scaffold over three-days by using chemicals to strip the ovarian tissue of all of its cells. "This is early days for the work but it's a very interesting proof of concept".

The approach has been garnering praise from the scientific community, but more research is needed.

A review published this year by Pors and her co-authors reported that a total of 318 women worldwide had undergone ovarian tissue transfers, with nine receiving a diagnosis of cancer afterward (in all cases not directly caused by the procedure).

This is an "exciting" technique, but still requires testing in humans, experts said.

While this process allows women to resume their periods and to conceive, it risks re-introducing cancerous cells. This could be the great future in which cancer patients are able to carry babies to term after being through radiotherapy and chemotherapy.

Related news:

Hot News

isis-killer-beheading-video-story-top We'd be at war with North Korea if it wasn't for me
Jul 05, 2018 - 02:41
However, on Tuesday, State Department spokeswoman Heather Nauert declined give a timeframe for North Korea's denuclearization. Secretary of State Mike Pompeo will depart for his third trip to North Korea on July 5, the White House announced Monday.

isis-killer-beheading-video-story-top European Union warns Trump that raised auto import tariffs would hurt US
Jul 05, 2018 - 02:21
By brawling with America's friends, critics say , Trump has squandered an opportunity to build a united front against China. The company has 10,000 jobs on site, as well as 40 suppliers in SC and 235 suppliers across the United States.

isis-killer-beheading-video-story-top Kidnappers Jailed for Violent Kidnapping of Halloween Actress
Jul 05, 2018 - 02:14
The following day, Jones and Amber Neal allegedly took McCrackin to two Bank of America locations and forced her to withdraw $100. At one point, while trying to protect McCrackin, he was severely beaten, punched and kicked for attempting to aid the actress.

isis-killer-beheading-video-story-top Liberty Island evacuated after statue base climber, banner
Jul 05, 2018 - 01:27
The demonstration was organized to protest the Trump administration's immigration policy, the group said in a press release. The protestor still sat at the base of the Statue of Liberty, near the foot of the monument, as of 5 p.m., he says.

isis-killer-beheading-video-story-top JK Rowling Puts Trump On Blast For His Sloppy Yet Ironic Tweeting
Jul 05, 2018 - 01:06
The president's tweets drew the attention of Rowling, who expressed her amusement in a series of tweets. Rowling and others on Twitter , including the account of the dictionary Merriam-Webster.

isis-killer-beheading-video-story-top Xfinity Mobile restricting hotspot and streaming video speeds
Jul 05, 2018 - 00:57
Folks sharing on Reddit have confirmed that Xfinity Mobile is planning to implement some throttling measures for certain features. Carriers argue that many consumers can't tell the difference between 480p and higher quality on smartphone screens.

isis-killer-beheading-video-story-top Brexit: Third customs model devised ahead of cabinet talks
Jul 05, 2018 - 00:27
It therefore seems likely that any third way will look more like the customs partnership than the max-fac model. The article drew a rebuke from Alan Duncan, a Foreign Office minister, who said he was being insolent.

isis-killer-beheading-video-story-top Comedian hires same lawyer as Stormy Daniels following Trump prank call
Jul 04, 2018 - 23:11
The White House is investigating how a call from a comedian was connected to President Trump as he was traveled on Air Force One. We got John out in the San Fernando Valley Sunday and talked to him about the prank call heard "round the world".

isis-killer-beheading-video-story-top Fallout 76 Also Won't Have Cross-Play and It's Sony's Fault
Jul 04, 2018 - 22:30
Bethesda certainly isn't the first to highlight Sony's lack of cross-play enthusiasm and we don't reckon they'll be the last.

isis-killer-beheading-video-story-top Ofcom Flooded With 650 Complaints As Dani Dyer Cries On 'Love Island'
Jul 04, 2018 - 22:27
He says: 'I just wanted to say I'm sorry, I didn't treat you very nicely, I was terrible , I let you down. And his former lover Ellie says she will not ruin his new romance and is busy flirting with Sam Bird .

isis-killer-beheading-video-story-top Arsenal boss Emery turns to Barcelona midfielder Andre Gomes
Jul 04, 2018 - 22:05
The Uruguay worldwide helped his national team to ease to a 2-1 win over Portugal in the World Cup round of 16 at the weekend.

isis-killer-beheading-video-story-top Hyundai says FCA buyout rumor 'totally groundless'
Jul 04, 2018 - 21:19
However, they confirmed to be open to a technical partnership to jointly develop future transmissions and hydrogen tech. The latest in the line will be Hyundai and Fiat Chrysler Automobiles, if reports are to be believed.

isis-killer-beheading-video-story-top Origi joins Liverpool teammates for first training
Jul 04, 2018 - 20:32
An astute coach, he lives and breathes every moment and that energy is clearly transmitted to his players. He recognises his team-mates and this club helped him achieve individual success last season.

isis-killer-beheading-video-story-top Philippine mayor who held drugs war 'walk of shame' shot dead
Jul 04, 2018 - 18:52
He said Halili's death may be considered a "revenge killing", considering relatives of EJK victims know the killers. Under the project, suspected drug dealers were paraded around the city streets for everyone to see.

isis-killer-beheading-video-story-top Nasa Hataoka drops to 23rd at Women's PGA Championship
Jul 04, 2018 - 18:26
Park beat So Yeon Ryu on the second hole of a playoff Sunday in the KPMG Women's PGA Championship . The scorching heat combined with a breeze helped dry out a course hit hard by rain this week.